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Cytometric fingerprints of gut microbiota predict Crohn’s disease state
Rubbens, P.; Props, R.; Kerckhof, F.-M.; Boon, N.; Waegeman, W. (2021). Cytometric fingerprints of gut microbiota predict Crohn’s disease state. ISME J. 15(1): 354-358. https://dx.doi.org/10.1038/s41396-020-00762-4
In: The ISME Journal: Multidisciplinary Journal of Microbial Ecology. Nature Publishing Group: London. ISSN 1751-7362; e-ISSN 1751-7370
Peer reviewed article  
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Authors  Top 
  • Rubbens, P.
  • Props, R.
  • Kerckhof, F.-M.
  • Boon, N.
  • Waegeman, W.
Abstract
    Variations in the gut microbiome have been associated with changes in health state such as Crohn’s disease (CD). Most surveys characterize the microbiome through analysis of the 16S rRNA gene. An alternative technology that can be used is flow cytometry. In this report, we reanalyzed a disease cohort that has been characterized by both technologies. Changes in microbial community structure are reflected in both types of data. We demonstrate that cytometric fingerprints can be used as a diagnostic tool in order to classify samples according to CD state. These results highlight the potential of flow cytometry to perform rapid diagnostics of microbiome-associated diseases.
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